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Export PDF . Example of exporting a map as a PDF . Example of exporting a map as a PDF using the jsPDF library. Related API documentation: ol.Map; ,; ol. from the lumen and then allows potassium to enter the interstitium across the basolateral membrane via potassium channels Regulation of potassium excretion involves multiple controls over the secretory processes in the distal nephron, something like a passenger van where everyone in it has an accelerator and a brake pedal As is the case with regulation of sodium excretion, we cannot predict just how these controls operate in every situation Fortunately, with potassium as well as sodium, the healthy kidneys do a remarkable job of doing the right thing, ie, increasing potassium excretion in response to high dietary loads and reducing excretion in the face of restricted diets Even with experimental manipulations, it is hard to get healthy kidneys to do otherwise (but as described later, certain pathologies interfere with normal potassium regulation) Much of the regulation involves controlling the activity of potassium channels. The kidneys and other body organs express numerous potassium channel species; for simplicity, we do not usually differentiate between types (Otherwise, we would have a whole book devoted entirely to potassium channels!) However in principal cells of the distal nephron two types of channels stand out as being those that secrete potassium in a regulated manner: ROMK (standing for renal outer medulla, because that is where they were first indentified) and BK (as each channel has a big capacity to secrete potassium) Owing to different combinations of channel subunits and alternative splicing of transcripts, several isoforms of each type of channel exist Although ROMK and BK channels both conduct potassium, they play different roles and are regulated by quite different mechanisms5 At very low dietary loads of potassium, there is virtually no secretion by either kind of channel. ROMK channels are sequestered in intracellular vesicles and BK channels are closed At normal potassium loads, ROMK channels are moved to the luminal membrane and secrete potassium BK channels are still closed, held in reserve and ready to respond to appropriate signals when needed At high excretion rates, both types of channel are present in the luminal membrane and avidly secreting potassium (Figure 8 3) Figure 8 4 shows factors known to influence the secretion, and thus the ultimate excretion of potassium The following text provides a brief description of how specific factors affect potassium excretion (1) Plasma potassium The role of plasma potassium is the most understandable influence First, the filtered load is directly proportional to plasma concentration Second, the environment of the principal cells, ie, the cortical interstitium, has a potassium concentration that is nearly the same as in plasma. jspdf jpg to pdf Jspdf add image multiple pages
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